scientist are starting to unravel the secret behind Ozempic / Wegovy and similar GLP-1 drug . In trial data print Thursday , researchers found evidence that GLP-1 therapy can perceptibly boost the organic structure ’s juicy - burn potential . The findings indicate that these drug are n’t helping citizenry lose weight just by boil down appetency , as some have suspect .
To further study this phenomenon , the team perform a belittled , randomized , and control trial with 30 patients who had obesity and obstructive sleep apnea , or OSA . OSA is often linked to obesity , and people with OSA also often have higher levels of visceral fat inflammation . So the researchers wanted to see if GLP-1 therapy could help these patients in particular .
masses in the control group received continuous confident airway pressure sensation ( CPAP ) machine , a gold - standard apnea intervention . Those in the 2nd grouping received liraglutide , a long - used GLP-1 drug for character 2 diabetes and corpulency , while the third mathematical group receive both liraglutide and CPAP therapy . To value their rich - combust power , the volunteers were founder PET - CT scan both before and six months into their discourse ( PET imaging uses a radioactive tracer bullet to evaluate how specific cell or tissues metabolize ) .
Injection pens of Victoza (liraglutide) and Wegovy (semaglutide).© Michael Siluk/UCG/Universal Images Group via Getty
compare to controls , the researchers found that the great unwashed on liraglutide experience a significant increase in their ability to burn up off visceral fat . Those who had lower baseline nonrational fat - tie in metabolism also tended to respond the honest to GLP-1 therapy , and those who project the biggest increases in metamorphosis were also more potential to lose more system of weights overall .
“ It always seemed overly simplistic to me that these new treatments were just make citizenry eat on less . So this study determination is an exciting measure forward in our understanding of how these newfangled medicines for fleshiness workplace , ” suppose study researcher Donal O’Shea , an endocrinologist at the University College Dublin and St Vincent ’s University Hospital Dublin , in astatement .
O’Shea and his team do remark that this research was a proof - of - concept study , so more work will be take to confirm the determination here . At the same meter , liraglutide is an old GLP-1 drug , and new medication like semaglutide ( Ozempic / Wegovy ) and tirzepatide ( Mounjaro / Zepbound ) are substantially more good at helping hoi polloi lose weight , with hoi polloi losing an average 15 % to 20 % of their body weighting in clinical trials . That could also intend that they ’re even better at helping us fire off fat — a question that the researchers hope others , include the drugmakers themselves , will continue to explore .
“ dependable aesculapian treatment for obesity is still in its early childhood and we need to understand to the full how the treatment works . Understanding how these agents increase push burn should be an important part of future research , ” O’Shea said .
OzempicSemaglutidesleep apneaWeight red
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